Beyond Reppe: Building Substituted Arenes by [2+2+2] Cycloadditions of Alkynes

摘要

Transition-metal-catalyzed cycloaddition reactions allow for the rapid construction of highly functionalized molecular frameworks in one step. The [2+2+2] cycloaddition reaction has become an effective tool for the synthesis of substituted arenes. There are a number of excellent procedures published that have utilized various transition metals to synthesize these targets. Recent developments in this area have focused mainly on an intermolecular approach to ring synthesis, while still maintaining the ability to control the substitution pattern of the resulting products. The purpose of this Highlight is to introduce the most recent attempts to solve the lingering problem of chemoselectivity in the intermolecular [2+2+2] cycloaddition reaction in the synthesis of arenes.