Unmasking a Third Polymorph of a Benchmark Crystal-Structure-Prediction Compound

摘要

The ability of a chemical substance to adopt more than one crystal structure is known as polymorphism, a phenomenon which can be both beneficial and problematic. Serendipity often plays a key role in the discovery of new forms, because no general methodology exists for producing new forms of a given compound. Understanding the origin of polymorphism and controlling the outcome of crystallization processes to avoid undesired forms is therefore a current goal.