Chemoselective Staudinger-Phosphite Reaction of Azides for the Phosphorylation of Proteins

摘要

Chemoselective reactions have become important tools in chemical research as well as in modern life sciences. They are used in the synthesis, for instance, of modified proteins for biological studies and thereby help in the evaluation of posttranslational modifications, such as phosphorylation or glycosylation, in signal transduction and regulation. In addition, biophysical probes or other functional modules can be introduced into complex biomolecules, even within a cellular environment, to visualize biological processes or specifically alter their functional behavior.