Total Synthesis of (+)-Dibromophakellin

摘要

(+)-Dibromophakellin (1), a member of a family of pyrrole-imidazole marine alkaloids, was isolated from Pseudoaxinyssa cantharella in 1985 as the enantiomer of natural (-)-dibromophakellin (ent-1) (Scheme 1). Neither enantiomer of phakellin (3/ent-3) has yet been isolated; however, 3 and ent-3 were obtained from 1 and ent-1, respectively, by hydrogenolysis. A number of related compounds have been isolated, together with dimeric analogues of palau'-amine and related congeners.