Stable Aziridinium Salts as Versatile Intermediates: Isolation and Regio-and Stereoselective Ring-Opening and Rearrangement

摘要

A variety of aziridinium cations have been generated in situ as precursors of enantiomerically pure organic compounds and biological active agents.Several aziridinium cations have been proposed as intermediates in the reaction of nitrogen mustards with interstrand cross-linked DNA.The ring-opening of substituted aziridinium cations has been recognized as an efficient synthetic route to chiral 1,2-and 1,3-diamines,3,4-diamino nitriles,nitrogen-containing hetero-cycles,and alpha,beta-diamino esters.