Gas-Phase versus Liquid-Phase Structures by Electrospray Ionization Mass Spectrometry

摘要

Electrospray ionization(ESI)is routinely used for the analysis of a wide variety of compounds which possess more than one ionization site.In cases where the most acidic or basic site differs in the gas-phase from that in solution an interesting question arises: Which species is produced? More specifically,is the liquid-phase ion structure preserved or does an isomerization take place during the evaporation and desolvation process?