Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase

摘要

Despite the fact that nearly 2 million people a year are killed by Mycobacterium tuberculosis (TB), we still lack a robust pipeline of potential therapies to combat this burden. Fragment-based approaches have provided a new paradigm in the development of high-quality chemical ligands and have great potential to contribute as starting points in the development of drugs against TB.