Asymmetric Self- and Cross-Aldol Reactions of Glycolaldehyde Catalyzed by D-Fruetose-6-phosphate Aldolase

摘要

Aldol additions are key chemical reactions for the construction of chiral complex polyhydroxylated molecules. Recent developments in direct aldol additions using bio-, organo-, and metal catalysts are promising since these methodologies do not require separate generation of enolate equivalents and thus improve the atom economy of the transformation. Aldehydes have been regarded as highly interesting donors in aldol reactions, because the products formed are themselves aldehydes that can be used in further aldol additions for the construction of complex polyfunctional molecular frameworks.