Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled

Ho-Jin Lee; Nick X. Wang; De-Li Shi

首页> 外文期刊>Angewandte Chemie >Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled

【24h】

Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled

机译：舒林酸通过阻断蛋白的PDZ结构域来抑制典型Wnt信号传导。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The protective anticancer effect of nonsteroidal anti-inflammatory drugs (NSAIDs) has attracted much attention, and clinical trials of several NSAIDs are under way for treatment or prevention of various cancers. As NSAIDs are best known for their inhibition of cyclooxygenase 1 and 2 (COX-1/ 2), they are hypothesized to suppress tumor growth by blocking prostaglandin synthesis.

机译：非甾体类抗炎药（NSAID）的保护性抗癌作用已引起广泛关注，并且几种NSAID的临床试验正在进行中，以治疗或预防各种癌症。由于NSAID以抑制环氧合酶1和2（COX-1 / 2）最为人所知，因此可以假设它们通过阻断前列腺素的合成来抑制肿瘤的生长。

著录项

来源
《Angewandte Chemie》 |2009年第35期|共5页
作者
Ho-Jin Lee; Nick X. Wang; De-Li Shi;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词
antitumor agents; hydrogen bonds signal inhibition; signal transduction;

机译：抗肿瘤药;氢键信号抑制;信号转导;

相似文献

外文文献
中文文献
专利

1. Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled [J] . Ho-Jin Lee, Nick X. Wang, De-Li Shi Angewandte Chemie . 2009,第35期

机译：舒林酸通过阻断蛋白的PDZ结构域来抑制典型Wnt信号传导。
2. Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/β-catenin complex [J] . Zhang H., Zhang H., Zhang Y., Cellular Signalling . 2010,第11期

机译：杂散的DEP结构域相互作用蛋白（DDIP）通过促进TCF4降解并破坏TCF4 /β-catenin复合物来抑制Wnt信号传导
3. Nuclear Factor of Activated T Cells (NFAT) Proteins Repress Canonical Wnt Signaling via Its Interaction with Dishevelled (Dvl) Protein and Participate in Regulating Neural Progenitor Cell Proliferation and Differentiation [J] . Tao Huang, Zhihui Xie, Jiyong Wang, The Journal of biological chemistry . 2011,第43期

机译：活化T细胞的核因子（NFAT）蛋白通过其与乳膏（DVL）蛋白的相互作用抑制规范WNT信号传导，并参与调节神经祖细胞增殖和分化
4. Liver Cancer Regression by an Immunotoxin Targeting Glypican-3 Through Inhibiting Wnt Signaling and Protein Synthesis [C] . Wei Gao, Zhewei Tang, Yifan Zhang, PEGS . 2015

机译：通过抑制WNT信号传导和蛋白质合成，通过免疫毒素靶向血糖毒素的肝癌回归
5. Isolation of dishevelled-interacting proteins and their role in Wnt signal transduction [D] . Strovel, Erin T. 1999

机译：衣壳相互作用蛋白的分离及其在Wnt信号转导中的作用
6. Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of Dishevelled [O] . Dr. Ho-Jin Lee, Dr. Nick X. Wang, Dr. De-Li Shi, -1

机译：舒林酸通过阻断杂乱无章的PDZ域来抑制规范Wnt信号。
7. The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish [O] . Teddy Young, Yogavalli Poobalan, Ee Kim Tan, 2014

机译：PDZ结构域蛋白MCC是斑马鱼的收敛和延伸期间非规范WNT信号传导的新效应器

Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled

摘要

著录项

相似文献

相关主题

期刊订阅