Biocompatible Functionalized Polyglycerol Microgels with Cell Penetrating Properties

摘要

Dendritic architectures, being globular structures with low viscosity and dense surface functionality, have become well established in chemical and biomedical applications. This description encompasses not only the monodisperse yet tediously synthesized perfect dendrimers, but also hyperbranched polymers which are typically obtained in one step and retain the favorable characteristics of perfect dendrimers. Hyperbranched polyglycerols (HPG), make up one such class of "dendrimer-like" polymers, traditionally synthesized by ring-opening polymerization of glycidol (3-hydroxypropylene oxide).