Enantioselective Intermolecular Crossed-Conjugate Additions between Nitroalkenes and alpha,beta-Enals through a Dual Activation Strategy

摘要

The electron withdrawing group(EWG)activated alkene is considered one of the most important building blocks in organic synthesis.Its primary reaction mode is the conjugate 1,4-addition(Michael addition).Recent developments within organocatalysis have led to the recognition of the enantioselective conjugate addition as one of the most important approaches to asymmetric C-C bond formation. The general strategy involves carbonyl activation via iminium intermediates.Moreover,such iminium catalysis has been incorporated into cascade(or domino)reactions,successful examples of which have been achieved by different research groups.