Barrier Compression Enhances an Enzymatic Hydrogen-Transfer Reaction

摘要

Although enzymes are efficient catalysts that can achieve unparalleled rate enhancements over the uncatalyzed reac-tion, the precise origin(s)of their catalytic power still remain unresolved after more than a century of research.The dominant paradigm of enzyme catalysis remains transition state theory(TST), in which the rate of the reaction is determined by the height of the reaction barrier, that is, the free energy of the transition state above the reactant state.