Convenient Preparation of Polyfunctional Aryl Magnesium Reagents by a Direct Magnesium Insertion in the Presence of LiCl

摘要

The preparation of complex polyfunctional organometallic reagents is of pivotal interest in organic synthesis.Recently,functionalized organomagnesium reagents have become accessible through a halogen/magnesium exchange or a directed metalation.During these studies it became apparent that aryl magnesium halides are compatible with important functional groups,such as cyano,nitro,ester,or even keto groups.This observation prompted us to reinvestigate the direct insertion of magnesium metal into aromatic and heterocyclic halides pioneered by Grignard.