Second-Generation Synthesis of Azadirachtin: A Concise Preparation of the Propargylic Mesylate Fragment

摘要

Azadirachtin(1)is a complex natural product which was first isolated from the Indian neem tree in 1968(Figure 1).It is a potent insect antifeedant and growth inhibitor;and this,combined with its challenging architecture,has generated great interest in its chemical synthesis.