Anti-MRSA Agent Discovery Using Diversity-Oriented Synthesis

摘要

Antibacterial drugs have played an essential role in the global increase in quality of life and life expectancy.However,these gains are at serious risk owing to bacterial drug resistance by so-called "superbugs",such as methicillin-resistant Staphylococcus aureus (MRSA).The discovery of new antibiotics with novel modes of action is vital to tackle the threat of multidrug-resistant bacteria.Traditionally,antibiotics have been discovered from natural sources;however,there are many disadvantages to using extracts (e.g.limited availability,bioactive constituent identification,and complex analogue synthesis).