Room Temperature Copper-Catalyzed 2-Functionalization of Pyrrole Rings by a Three-Component Coupling Reaction

摘要

The efficient construction of a O-C bond is an important process in modern synthetic chemistry.In particular,the functionalization of heterocycles such as pyrrole units,which have utility in organic synthesis and medicinal chemistry,relies on the C-C bond forming strategies.A wide range of synthetic strategies involving Friedel-Crafts reactions have been devised.