Silicon-Based Building Blocks for One-Step ~(18)F-Radiolabeling of Peptides for PET Imaging

摘要

Positron emission tomography (PET) is an important diagnostic tool in modern medicine due to its ability to locate and assess abnormalities in neurology, oncology, and cardiology. The application of ~(18)F-labeled small bioactive peptides for diagnostic imaging has emerged as an important and interesting field in nuclear medicine. However, currently established ~(18)F-labeling procedures require scrupulously dry, strongly basic reaction conditions at high temperature, which are not suitable for biomolecules such as peptides and proteins.