Organocatalytic Asymmetric Domino Reactions: A Cascade Consisting of a Michael Addition and an Aldehyde α-Alkylation

摘要

The development of asymmetric reactions using small organic molecules as catalysts, which are often nontoxic, environmentally friendly, and stable under aerobic and aqueous reaction conditions, has attracted much attention in recent years. Domino reactions provide an efficient means to construct complex molecules in a single process, while minimizing the number of manual operations and the generation of chemical waste and easing purification. Organocatalytic domino reactions can combine these advantages, and many interesting reactions have been developed during the past few years.