The Structure of the Neuropeptide Brady kinin Bound to the Human G-Protein Coupled Receptor Bradykinin B2 as Determined by Solid-State NMR Spectroscopy

摘要

G-protein coupled receptors(GPCRs)are responsible for a large number of physiological processes,such as sensory transduction,mediation of hormonal activity,and cell-to-cell communication.GPCRs are membrane proteins with seven transmembrane helices and are the target of some 50% of modern drugs.They constitute the largest known protein family and have had more than 800 species identified in the search for medical solutions to human illnesses.