Chiral Bronsted Acid Catalyzed Asymmetric Baeyer-Villiger Reaction of 3-Substituted Cyclobutanones byUsing Aqueous H2O2

摘要

The Baeyer-Villiger (BV) reaction represents one of the most well-known and widely applied reactions in organic synthesis.Although more than one century has gone by since its discovery in 1899,the BV reaction is still far from being fully developed.Although the use of aqueous hydrogen peroxide as an environmentally benign oxidant has been a long-sought goal for the BV reaction,significant efforts still need to be made in the area of enantioselective BV reactions.Since the pioneering work by the groups of Strukul and Bolm in 1994,a number of chiral metal complexes or organic molecules have been developed as promoters or catalysts for the BV reaction of various ketones,but there are only a few cases in which the catalysts are used in combination with aqueous hydrogen peroxide as the oxidant.