Heterogeneously Catalyzed Efficient Oxygenation of Primary Amines to Amides by a Supported Ruthenium Hydroxide Catalyst

摘要

Amides are a very important class of compounds in chemistry and biology that have been used as intermediates in peptide and protein synthesis,intensifiers of perfume,anti-block reagents,color pigments for inks,detergents,and lubricants.Traditionally,amides have been synthesized by the reaction of activated carboxylic acid derivatives,such as acid chlorides,anhydrides,and esters with amines including ammonia or by the acid-catalyzed rearrangements of ketoximes.However,these traditional methods often produce vast amounts of toxic chemical by-products.Therefore,the development of efficient procedures for the synthesis of amides that avoid the wasteful use of stoichiometric reagents and/or acidic and basic media is highly desirable and still a great challenge in modern organic synthesis.