Asymmetric Palladium-Catalyzed Intramolecular α-Arylation of Aldehydes

摘要

The prevalence of chiral quaternary stereocenters in many natural products has attracted a growing interest in the development of methods for their construction with absolute stereocontrol. In recent years, the α-arylation of carbonyl compounds has received a great deal of attention. Despite substantial advances, the asymmetric metal-catalyzed α-arylation of carbonyl compounds remains a formidable challenge, and few examples have been described.To the best of our knowledge, no examples of asymmetric metal-catalyzed α-arylation of aldehydes have yet been reported. Herein, we present the first asymmetric metal-catalyzed α-arylation of aldehydes forming all-carbon-substituted asymmetric centers in high yields and enantioselectivities (Scheme 1).