Visual Detection of Copper(II) by Azide- and Alkyne-Functionalized Gold Nanoparticles Using Click Chemistry

摘要

We report a method for the detection of Cu~(2+) ions by azide-and terminal alkyne-functionalized gold nanoparticles (Au NPs) in aqueous solutions using click chemistry. The catalyst, Cu(I), was conveniently derived from the reduction of Cu(II) in the presence of sodium ascorbate. This method allows the naked eye, without the aid of any advanced instrument, to assay for the presence of Cu~(2+) ions by the aggregation of Au NPs as a result of the Cu(I)-catalyzed conjugation between the two functional groups.