Small-Molecule Inhibitors of Islet Amyloid Polypeptide Fibril Formation

摘要

Newly synthesized proteins in the cell adopt a functional folded state resulting from a highly regulated process.Failure to form this functional state leads to the degradation of proteins inside the cell.However,under certain conditions,some proteins can also adopt an alternative state by the assembly of unfolded or partially folded monomers or protein fragments into a P-sheet structure called amyloid fibril.