Highly Enantioseleetive Hydrogenatlon of Aryl Vinyl Ketones to Allylic Alcohols Catalyzed by the Tol-Binap/Dmapen Ruthenium(II) Complex

摘要

Enantioselective hydrogenation of prochiral ketones (R~1COR~2, R~1≠R~2) requires distinction between two sub-stituents, R1 and R2, connected to the carbonyl group. In the reaction of functionalized ketones, α, β, or γ-hetero-substi-tuted alkyl moieties are accurately discriminated from simple alkyl groups by means of chirally modified transition-metal catalysts.