Enantioselective C-C Bond Activation of Allenyl Cyclobutanes:Access to Cyclohexenones with Quaternary Stereogenic Centers

摘要

The transition-metal-catalyzed activation of carbon-carbon a bonds has the potential to change organic synthesis fundamentally.However,the practical implementation of this concept is still a major challenge;in particular,there are few examples of enantioselective C-C activation.Small strained rings occupy a privileged position in C-C activation reactions because of the energy released by strain reduction in ring-opening reactions.