Experimental Evidence That a DNA Polymerase Can Incorporate N7-Platinated Guanines To Give Platinated DNA

摘要

Incorporation into DNA of nucleotides linked to functional groups has a variety of potential applications.Several organic reporter groups,covalently linked to nucleotides,are already widely used as experimental tools for nucleic acid modification.Extensive studies on the synthesis,structure,and properties of metalated nucleotides,oligonucleotides,DNA,and RNA,mainly but not solely cisplatin related,have been reported.