Highly Efficient Ruthenium(II)Porphyrin Catalyzed Amidation of Aldehydes

摘要

The installation of the amide bond functionality is of immense interest in organic synthesis owing to the prevalence of this structural motif in a myriad of compounds of biological,pharmaceutical,and materials interest.Conventional routes to this ubiquitous class of nitrogen-containing compounds have relied heavily upon the coupling of activated carboxylic acid and amine precursors.Although these methodologies have been shown to be exceptionally efficient for the synthesis of small peptides,many classes of amides,including those found in many natural products,bioconjugates,and pharmaceutical targets,along with the lability of the activated carboxylic acid derivatives,pose significant challenges.