Enantioselective Synthesis of Arglabin

摘要

A prominent member of the widely distributed class of guaianolides is arglabin,which inhibits farnesyl transferase and thus activation of the RAS proto-oncogene,a process that is believed to play a pivotal role in 20-30% of all human tumors.The natural product shows promising antitumor activity and cytotoxicity against different tumor cell lines(human tumor cell lines IC_(50)= 0.9-5.0 mu gmL~(-1)).