A Formally Zwitterionic Ruthenium Catalyst Precursor for the Transfer Hydrogenation of Ketones that Does Not Feature an Ancillary Ligand N-H Functionality

摘要

The ruthenium-mediated transfer hydrogenation(TH)of ketones under basic conditions employing iPrOH or other H2-donor solvents has emerged as an atom-economical method ology for the synthesis of secondary alcohols.Although the catalytic abilities of Ru complexes supported by a range of structurally diverse ancillary ligands have been evaluated,precatalysts featuring a Ru-NH linkage commonly offer the highest levels of activity and selectivity in the TH of ketones.