Isolation and Structure of Platencin:A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity

摘要

The discovery of antibiotics for the treatment of bacterial infections has been one of the most important medical achievements of the past 60 years.However,the emergence of bacterial resistance to current antibiotics is a major challenge faced by the medical community.The emergence of resistance is inevitable,and hence the continued discovery of novel chemotype antibiotics with novel modes of action is critical to overcome drug-resistant organisms.