Mechanistic Studies of Proton-Donor Coordination to Samarium Diiodide

摘要

Alcohols,glycols,and glymes are commonly used as additives in numerous reductions and reductive coupling reactions of samarium diiodide(SmI2).Typically alcohols and glycols are used as proton donor sources,whereas glymes are used as coordinating additives.All of these additives have been shown to exert an influence on the regiochemical and stereochemical outcomes of numerous SmI2-mediated reactions.The seminal work of Hoz et al.demonstrated that the interplay between proton-donor coordination and acidity is likely to play an important mechanistic role in reductions.