A Concise Total Synthesis of the Notoamides C and D

摘要

The past several years have seen an explosion of new metabolites that are isolated from fungi and have interesting biological activities. Our research group has a rich history in the synthesis and elucidation of the biosynthesis of fungal metabolites derived from tryptophan, isoprene, proline, and proline derivatives. Recently, two research groups have reported structurally related alkaloids that were isolated from two different strains of fungi, cultivated from marine environments. Tsukamoto and co-workers recently isolated four new prenylated indole alkaloids named the notoamides A-D (1-4, Scheme 1), along with the known alkaloids sclerotiamide and stephacidin A (9), from a marine strain of Aspergillus sp. cultivated from the common mussel, Mytilus edulis.