A Domino Sequence Consisting of Insertion,Coupling,Isomerization,and Diels-Alder Steps Yields Highly Fluorescent Spirocycles

摘要

The coupling-isomerization reaction (CIR,[Eq.(1)],EWG = electron-withdrawing group) of electron-deficient (hetero)aryl halides and (hetero)arylpropargyl alcohols under the conditions of the Sonogashira coupling is a mild and efficient route to enones,in particular,to l,3-di(heter-o)arylpropenones,known as chalcones.In the past years this new chalcone synthesis has been applied to novel consecutive one-pot multicomponent syntheses of pharmaceutically relevant heterocycles.