Stereoseleetive Syntheses of Peptide Derivatives with 2-Acetamido-3,4,6-tri-0-acetyl-i1amino-2-deoxy-β-D-glueopyr3nose by Four-Component Condensation

摘要

Syntheses that feature the simultaneous reaction of several re-actants in a one-pot procedure are called multicomponent reactions (MCRs). In 1850 A. Sirecker discovered a reaction, subsequently named after him. which in our nomenclature is formulatedas S-3CR. and in which ammonia, carbonyl compounds, and hydrogen cyanide react to form α-aminoaikyl cyanides that can he bydroiyzed to the corresponding arnino acids. Since 1934 α-amino acids have been obtained by the Bucherer- Bergs reaction (BB-4CR),one of the very first 4CRs.