Clinical significance of serum BAP, TRACP 5b and ICTP as bone metabolic markers for bone metastasis screening in lung cancer patients

摘要

Background: We investigated the clinical significance of serum bone-specific alkaline phosphatase (BAP), tartrate-resistant acid phosphatase isoform 5b (TRACP 5b) and type I collagen carboxyterminal telopeptide (ICTP) as bone metabolic markers for bone metastasis (BM) screening in lung cancer patients. Methods: Newly diagnosed advanced lung cancer patients with (N= 130) and without (N= 135) BM were enrolled in the study. Serum BAP, TRACP 5b and ICTP were measured before the treatment. Results: BAP, TRACP 5b and ICTP values were higher in patients with BM compared with patients without BM (all P< 0.0001). Area under ROC curve (AUC) of BAP, TRACP 5b and ICTP was 0.760, 0.753 and 0.835 (all P< 0.0001), respectively. The cut-off values for BAP, TRACP 5b and ICTP were 21.8. μg/l, 7.8 U/l and 8.8. μg/l, respectively. When TRACP 5b and ICTP were combined, AUC was elevated to 0.895 (P<. 0.0001), and the cut-off values were TRACP 5b 7.6 U/l and ICTP 8.4. μg/l. Conclusions: We conclude that serum BAP, TRACP 5b and ICTP may serve as useful tools for BM screening in lung cancer patients.