Polysaccharide-Based Hydrogels: Preparation,Characterization, and Drug Interaction Behaviour

摘要

Oxidized alginate (ADA) and oxidized alginate blended with chitosan (ADA-Chit) were prepared in the presence of borax and CaCl2,and their interactions with an antifolate drug,pyrimethamine (PYR),have been investigated.Tablets with a mean diameter of 1.2 ± 0.06 cm were produced and drag interactions were performed in dimethyl sulfoxide (DMSO) using isothermal titration calorimetry (ITC).From ITC responses,the enthalpy changes of interaction PYR/materials,△_(int)H,have been determined and were found to be -11.73 ± 0.517 kJ mol~(-1) for ADA and -4.86 ± 0.156 kJ mol~(-1) for ADA-Chit.The PYR encapsulation of approximately 75% was achieved for both materials,as measured by UV spectrometer.