Lithium perchlorate suspend in methylene chloride, a mild, efficient and reusable catalyst for the synthesis of ferrocene aminonitrile derivatives

摘要

A practical and efficient method for the synthesis of alpha-aminonitriles of ferrocene by one-pot three-component reaction of ferrocenecarboxaldehyde, trimethylsilyl cyanide and amines catalyzed by lithium perchlorate suspend in CH2Cl2, is reported under mild and neutral reaction conditions in high yields and short reactions times. (C) 2004 Elsevier B.V. All rights reserved.