A conventional method of avoiding normal tissue overheating during focused ultrasound surgery (FUS) is to apply equal heating duration for each sonication in between cooling intervals. However, this method is time-consuming and expensive. A novel method with unequal heating duration in different scanning paths without cooling intervals was investigated in this paper. This method was compared with the conventional method through the ablation of a 10 x 10 cm(2) target. The simulation results indicated that the new method was able to reduce treatment time by more than 50%, with higher than 95% coverage index, and more uniform thermal dose distribution. The method was further verified through the ablation of a circular lesion. Ex vivo experiments were also performed to confirm the simulation results. Both simulation and experimental results have proven that the new method can increase heating efficiency, and are a promising new approach in FUS.
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机译：避免在聚焦超声手术（FUS）期间正常组织过热的常规方法是在冷却间隔之间为每个超声处理施加相等的加热持续时间。但是，这种方法既费时又昂贵。本文研究了一种新的方法，该方法在不同的扫描路径上具有不相等的加热持续时间，而没有冷却间隔。通过消融10 x 10 cm（2）的目标，该方法与常规方法进行了比较。仿真结果表明，该新方法能够将治疗时间减少50％以上，覆盖指数高于95％，并且热剂量分布更加均匀。通过消融圆形病变进一步验证了该方法。还进行了离体实验以确认模拟结果。仿真和实验结果均证明该新方法可以提高加热效率，并且是FUS中有希望的新方法。
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