Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors.

Ting PC; Lee JF; Anthes JC; Shih NY; Piwinski JJ

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Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors.

机译：作为双NK1 / NK2抑制剂的取代4（Z）-（甲氧基亚氨基）戊基-1-哌啶的合成。

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摘要

The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-4(Z)-(methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors.

机译：一系列5-[（3,5-双（三氟甲基）苯基）甲氧基] -3-（3,4-二氯苯基）-4（Z）-（甲氧基亚氨基）戊基-1-哌啶的NK1和NK2受体活性被评估。发现化合物11d，11e，11f，12a和12k是我们最有效的抑制剂。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2001年第4期|共4页
作者
Ting PC; Lee JF; Anthes JC; Shih NY; Piwinski JJ;
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正文语种 eng
中图分类药学;生物化学;
关键词
Piperidines; Receptors; Neurokinin-1; Receptors; Neurokinin-2; 哌啶类; 受体; 神经激肽1; 受体; 神经激肽2;

机译：Piperidines;Receptors;Neurokinin-1;Receptors;Neurokinin-2;哌啶类;受体;神经激肽1;受体;神经激肽2;

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1. Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors. [J] . Ting PC, Lee JF, Anthes JC, Bioorganic and Medicinal Chemistry Letters . 2001,第4期

机译：作为双NK1 / NK2抑制剂的取代4（Z）-（甲氧基亚氨基）戊基-1-哌啶的合成。
2. Design and synthesis of 3,5-disubstituted benzamide analogues of DNK333 as dual NK1/NK2 receptor probes. [J] . Swarna VM, Undem BJ, Korlipara VL Bioorganic and Medicinal Chemistry Letters . 2007,第4期

机译：DNK333的3,5-二取代的苯甲酰胺类似物的设计和合成，作为双NK1 / NK2受体探针。
3. The design and synthesis of novel NK1/NK2 dual antagonists. [J] . Reichard GA, Ball ZT, Aslanian R, Bioorganic and Medicinal Chemistry Letters . 2000,第20期

机译：新型NK1 / NK2双重拮抗剂的设计与合成。
4. Synthesis and Biological study of 2-( 5-aryl-4,5-dihydro-1-substituted-pyrazol-3-yl )-substituted-naphthalene-1 -ol [C] . SUBODH BHANDARKAR, BHAVANA KHOBRAGADE International Conference on Advanced Materials Development Performance . 2015

机译：2-（5-芳基-4,5-二氢-1-取代-Pyrazol-3-基-1- 1-醇的合成与生物学研究 - 萘-1- 1-ol
5. The design and synthesis of novel ligands for the somatostatin and NK1 receptors incorporating the beta-D-glucoside scaffold and related mimetics of peptidal beta-turns. [D] . Angeles, Angie Reyes. 2005

机译：设计和合成的生长激素抑制素和NK1受体的新型配体结合了β-D-葡萄糖苷支架和相关的肽β-turns模拟物。
6. Simultaneous detection of decidual Th1/Th2 and NK1/NK2 immunophenotyping in unknown recurrent miscarriage using 8-color flow cytometry with FSC/Vt extended strategy [O] . Peng Dong, Xi Wen, Jia Liu, 2017

机译：使用FSC / Vt扩展策略的8色流式细胞术同时检测未知复发流产中的蜕膜Th1 / Th2和NK1 / NK2免疫表型
7. Simultaneous detection of decidual Th1/Th2 and NK1/NK2 immunophenotyping in unknown recurrent miscarriage using 8-color flow cytometry with FSC/Vt extended strategy [O] . Peng Dong, Xi Wen, Jia Liu, 2017

机译：用FSC / VT扩展策略的8色流式细胞术，同时检测未知的复发性流产中未知的复发性误差的蜕膜间隙
8. Evidence of NK1 and NK2 Tachykinin Receptors and their Involvement in HistamineRelease in a Murine Mast Cell Line [R] . Krumins, S. A., Broomfield, C. A. 1992

机译：NK1和NK2速激肽受体的证据及其在小鼠肥大细胞系中对组胺释放的参与

Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors.

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