Modified synthesis and antiangiogenic activity of linomide.

Khan SR; Mhaka A; Pili R; Isaacs JT

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Modified synthesis and antiangiogenic activity of linomide.

机译：利诺米特的修饰合成和抗血管生成活性。

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摘要

A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.

机译：描述了合成亚胺化物的改进方法。表征合成的药物并评估其体内抗血管生成活性。在鼠类血管生成测定中，如减少的微血管面积和血容量所证实，利诺米特治疗抑制了新血管的形成。

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《Bioorganic and Medicinal Chemistry Letters》 |2001年第4期|共2页
作者
Khan SR; Mhaka A; Pili R; Isaacs JT;
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正文语种 eng
中图分类药学;生物化学;
关键词
Angiogenesis Inhibitors chemical synthesis; Hydroxyquinolines; Angiogenesis Inhibitors; 羟喹啉类;

机译：血管生成抑制剂化学合成羟基喹啉血管生成抑制剂羟喹啉类;

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1. Modified synthesis and antiangiogenic activity of linomide. [J] . Khan SR, Mhaka A, Pili R, Bioorganic and Medicinal Chemistry Letters . 2001,第4期

机译：利诺米特的修饰合成和抗血管生成活性。
2. Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities [J] . Maiy Y. Jaballah, Rabah A. T. Serya, Nasser Saad, Journal of enzyme inhibition and medicinal chemistry. . 2019,第1期

机译：寻求具有强抗血管生成活性的新型支架;哒嗪类化合物的设计，合成，铰链相互作用的影响及其生物活性构象对VEGFR-2活性的可及性
3. A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos. [J] . Vollmer LL, Jimenez M, Camarco DP, Molecular cancer therapeutics . 2011,第6期

机译：一种新的dictyostatin类似物的简化合成，该合成物具有体外抗埃博霉素B耐药细胞的活性以及斑马鱼胚胎中的抗血管生成活性。
4. Synthesis and Activity on Modified TiO_2 Coated on Modified Serpentine [C] . WuYa-rui, ChenQiu-ji, WangSong International Conference on Energy, Environment and Sustainable Development . 2014

机译：改性蛇形改性TiO_2的合成与活性
5. Synthesis of side chain-modified iodothyronines. Synthesis and structure-activity relationships (SARS) of galanthamine derivatives. Total synthesis of (+)-valyldetoxinine. Synthesis and mechanism of cyclic acetal and ketal formation in pentono-1,4-lactones. [D] . Han, So-Yeop. 1992

机译：侧链修饰的碘甲状腺素的合成。加兰他敏衍生物的合成及其构效关系（SARS）。（+）-Valyldetoxinine的全合成。戊通-1,4-内酯中环状缩醛和缩酮的合成及其机理。
6. Towards discovery of novel scaffold with potent antiangiogenic activity; design synthesis of pyridazine based compounds impact of hinge interaction and accessibility of their bioactive conformation on VEGFR-2 activities [O] . Maiy Y. Jaballah, Rabah A. T. Serya, Nasser Saad, 2019

机译：旨在发现具有有效抗血管生成活性的新型支架；哒嗪类化合物的设计合成铰链相互作用的影响及其生物活性构象对VEGFR-2活性的可及性
7. A simplified synthesis of novel dictyostatin analogues with In Vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos [O] . Vollmer, LL, Jiménez, M, Camarco, DP, 2011

机译：新型dictyostatin类似物的简化合成，其对埃博霉素B耐药细胞具有体外活性，在斑马鱼胚胎中具有抗血管生成活性
8. Antiangiogenic Action of Chemically Modified Tetracyclines in Breast Cancer [R] . Simon, S. R. 2005

机译：化学修饰四环素对乳腺癌的抗血管生成作用

Modified synthesis and antiangiogenic activity of linomide.

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