In vivo studies on analgesic, antipyretic, motor coordination and memory enhancing activities of polyherbal preparation used in reference to male antifertility and aphrodisiac activity in albino rats.

摘要

The objective of this study was to investigate the pharmacological profile of the male antifertility polyherbal preparation (MAPP) and aphrodisiac polyherbal preparation (APP) in male albino rats with experiments on Eddy's Hot Plate, Tail Suspension Test (TST), Digital telethermometer, Rota Rod Apparatus and Cook's Pole Climbing Apparatus in reference to analgesic, antipyretic, motor coordination and memory enchancing activity to settle the fact that the MAPP and APP has no overt organ specific toxicity. The Hot Plate Test revealed that the MAPP and APP have moderate analgesic activity at 500 mg/kg dose which could be potential useful for the development of antinociceptive activity in the management of induced pain. The MAPP and APP showed dose dependent inhibition of acetic acid induced writhings in albino rats which was more potent than aspirin. The TST clearly indicated that Diclofenac Sodium and MAPP and APP showed nearly equal activity and have no effect of acute toxicity and doses from 50 to 500 mg/kg body weight to the test animals. The significant and maximum antipyretic activity of MAPP and APP was not at all dose dependent when compared with the treated control. None of the polyherbal preparation treatment showed significant impaired motor coordination compared to the control group at any dose level. Conditioned avoidance response (CAR) using Cook's Pole Climbing Apparatus in normal and Benzodiazepines induced amnestic rats at dose of 150, 300 and 500 mg/kg b. wt. reflected changes in cognition as determined by the acquisition, retention and recovery in rats were dose dependent. Based on the present results from this study it is clear that MAPP and APP has potential male antifertility and aphrodisiac properties and can be useful for alternative and cost effective therapy specially in developing countries where income is low and the majority of the people rely on herbal remedies.