SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists.

摘要

The discovery of the potency-enhancing effect of 5-substitutions on the novel 2-arylindoles as nonpeptidyl GnRH receptor antagonists led to the identification of several analogues with high affinities on the GnRH receptor. The syntheses and SARs of these 5-substituted-2-arylindole analogues are reported.