Synthesis, spectroscopy, in vitro biological activity and X-ray structure of (4-Methylpiperidine-dithiocarbamato-S,S ')triphenyltin(IV)

摘要

(4-Methylpiperidine-dithiocarbamato-S,S')triphenyltin(IV) derivative of 4-methyl-1-piperidine carbodithioic acid (4-MePCDTA) have been synthesized and characterized by elemental, IR, multinuclear NMR (H-1 and C-13) and mass spectrometric studies. The crystal structure of the complex has been determined by X-ray single crystal analysis, which shows unsymmetrical nature of the ligand towards coordination to tin. It crystallizes in monoclinic P21/c space group with the crystal cell parameters: a = 10.1863(10) angstrom, b = 21.200(2) angstrom, c = 11.7332(11) angstrom, beta = 111.2020(10)degrees, Z = 4 and V = 2,362.2(4) angstrom(3). The tin atom is coordinated to the two sulfur atoms of the dithiocarbamate ligand and three carbon atoms of the phenyl groups are in distorted trigonal bipyramid geometry. This complex was tested for its antimicrobial activity against six different plant and human pathogens. The screening results show that the complex exhibit higher antibacterial and antifungal activity than the free ligand.