Bone-bonding ability of bioactive bone cement under mechanical stress.

摘要

Bioactive bone cement (BABC) is able to bond to bone through a Ca-P rich layer. It was evaluated so far in a rat tibial model, where no mechanical stresses are supposed to take place. The objective is to investigate the behavior of BABC in the environment of posterolateral spinal fixation model, in which the bone cement interface is exposed to continuous mechanical stress. Japanese white rabbits were used. Fixation of L5-L6 segment was done by wiring the spinous and transverse processes of L5 and L6 vertebrae. Then BABC was applied over the transverse processes and the intertransverse process membrane on both sides. Polymethylmethacrylate (PMMA) bone cement was used similarly in the control group. Animals were sacrificed after 1 day, 4, 8, and 16 weeks postoperatively. Bone cement interface was examined using Giemsa surface staining and SEM, and affinity index was measured. Biomechanical testing was done nondestructively in right and left torsion. BABC bonded to bone directly with no intervening soft tissue at 4, 8, and 16 weeks, while soft tissue was consistently seen between PMMA bone cement and bone. BABC-spine constructs were stiffer than PMMA-spine constructs at all time intervals. BABC bonded directly to bone under mechanical stress and afforded stiffer fixation than PMMA bone cement. Copyright 1999 John Wiley & Sons, Inc.