Evaluation of a Sphere-Templated Polymeric Scaffold as a Subcutaneous Implant

摘要

Objective: To evaluate the performance of a sphere-templated poly(2-hydroxyethyl methacrylate) (poly-[HEMA]) tissue scaffold as a subcutaneous implant by comparing it with widely used high-density porous polyethylene (HDPPE) implant material.Design: We implanted sphere-templated porous poly-(HEMA) and HDPPE disks into the dorsal subcutis of C57BL/6 mice for 4 and 9 weeks. Excisional biopsy specimens of the implants and surrounding tissue were assessed for host inflammatory response, tissue ingrowth, and neovascularization using trichrome, picrosirius red, and anti-endothelial cell antibody staining.Results: The poly(HEMA) and HDPPE implants showed resistance to extrusion and elicited a minimal inflammatory response.