Synthesis of new (1,3,4)thiadiazolo(3,2-a)thieno(2,3-d)pyrimidinone derivatives with antiinflammatory activity.

Modica M; Santagati M; Santagati A; Cutuli V; Mangano N; Caruso A

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Synthesis of new (1,3,4)thiadiazolo(3,2-a)thieno(2,3-d)pyrimidinone derivatives with antiinflammatory activity.

机译：具有抗炎活性的新的（1,3,4）噻二唑（3,2-a）噻吩并（2,3-d）嘧啶酮衍生物的合成。

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New thiadiazolothienopyrimidinones were synthesized in continuation of efforts to prepare thienopyrimidine derivatives with analgesic and antiinflammatory activities. In this study, the effect of various substituents in the thiophene ring on the pharmacological activity of the compounds was investigated.

机译：在继续努力制备具有镇痛和抗炎活性的噻吩并嘧啶衍生物的过程中，合成了新的噻二唑并噻吩并嘧啶酮。在这项研究中，研究了噻吩环中各种取代基对化合物药理活性的影响。

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《Die Pharmazie》 |2000年第7期|共3页
作者
Modica M; Santagati M; Santagati A; Cutuli V; Mangano N; Caruso A;
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正文语种 eng
中图分类药学;
关键词
Anti-Inflammatory Agents; Non-Steroidal; Pyrimidinones; Thiazoles; Analgesics; 消炎药; 非甾类; 嘧啶酮类; 噻唑类;

机译：Anti-Inflammatory Agents;Non-Steroidal;Pyrimidinones;Thiazoles;Analgesics;消炎药;非甾类;嘧啶酮类;噻唑类;

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1. Synthesis of new (1,3,4)thiadiazolo(3,2-a)thieno(2,3-d)pyrimidinone derivatives with antiinflammatory activity. [J] . Modica M, Santagati M, Santagati A, Die Pharmazie . 2000,第7期

机译：具有抗炎活性的新的（1,3,4）噻二唑（3,2-a）噻吩并（2,3-d）嘧啶酮衍生物的合成。
2. Synthesis and Anticancer Activity of Novel Substituted 1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine and 1,3,4-thiadiazolo-[3,2-a]-1,3,5-triazine Derivatives [J] . Deepak Kumar Basedia, Birendra Shrivastava, B. K. Dubey Asian journal of research in chemistry . 2014,第3期

机译：新型取代的1,3,4-恶二唑-[3,2-a] -1,3,5-三嗪和1,3,4-噻二唑-[3,2-a] -1,3的合成及抗癌活性，5-三嗪衍生物
3. A Convenient access to Functionalized 1,3,4-Thiadiazole, Thiazole, Thiophene, Thieno[2,3-d]pyrimidine, Pyrimidine, and Thiazolo[3,2-a]pyrimidine Derivatives [J] . Ahmad M. Farag, Nabila A. Kheder, Kamal M. Dawood American Journal of Organic Chemistry . 2015,第2期

机译：方便获得功能化的1,3,4-噻二唑，噻唑，噻吩，噻吩并[2,3- d ]嘧啶，嘧啶和噻唑并[3,2- a ]嘧啶衍生物
4. Synthesis, characterization of some new l,3-oxazine-4-one derivatives containing 1,3,4-oxadiazole and 1,3,4-thiadiazole moiety with screening some of their biological activity. [C] . Raneen Hashim Rida, Maysoon Tariq Tawfiq International Scientific Conference on Pure Sciences, Brilliant Creativity and Renewed Building . 2019

机译：合成，表征一些含有1,3,4-二唑和1,3,4-噻二唑部分的一些新的L，3-氧嗪-4-一种衍生物，其具有筛选其一些生物活性。
5. I. SYNTHETIC APPROACHES TO SUBSTITUTED 2-OXABICYCLO(3.2.1)OCTANE DERIVATIVES AND II. THE SYNTHESIS OF 1-SUBSTITUTED DERIVATIVES OF ANHYDRO (3-CHLOROACETYL-2-HYDROXYIMIDAZO(1,2-A)PYRIDINIUM HYDROXIDE). [D] . FRIEDMAN, ALAN E. 1973

机译：I.取代2-氧杂双环（3.2.1）正己烷衍生物的合成方法和II。合成1-取代的酸酐（3-氯乙酰基-2-羟基咪唑并（1,2-A）吡啶鎓氢氧化物）。
6. Synthesis and Biological Evaluation of Thieno32-d- pyrimidinones Thieno32-dpyrimidines and Quinazolinones: Conformationally Restricted 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2) Inhibitors [O] . Enrico Perspicace, Sandrine Marchais-Oberwinkler, Rolf W. Hartmann 2013

机译：噻吩并32-d-嘧啶酮噻吩并32-d嘧啶和喹唑啉酮的合成及生物学评价：构象受限的17β-羟基类固醇脱氢酶2型（17β-HSD2）抑制剂。
7. The Synthesis of 1,3,4-Oxadiazolo3,2-bisoquinoline and 1,3,4-Thiadiazolo-3,2-bisoquinoline Derivatives from Homophthalic Anhydride [O] . Masahiko Takahashi, Takamitsu Shinoda, Hideshi Osada, 1975

机译：1,3,4-氧基唑的合成来自同律邻苯二甲酸酐的1,3,4-氧代唑3,2-B异喹啉和1,3,4-噻二唑-3,2-B异喹啉衍生物

Synthesis of new (1,3,4)thiadiazolo(3,2-a)thieno(2,3-d)pyrimidinone derivatives with antiinflammatory activity.

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