Liberation of hydrocortisone acetate from different commercial formulations

摘要

Liberation of hydrocortisone acetate from different commercial formulations In this article the release of hydrocortisone acetate (HC-acetate) from three commercial semisolid formulations (Ebeno-ointment, Soventol HC cream and Fenistil hydrocortisone ointment) was measured by means of a multilayer membrane system (MLMS) described in the literature. The formulations are different regarding rate and extent of the release of HC-acetate. The release of HC-acetate form the Soventol HC cream is very fast and results in high topical availability. In contrast, HC-acetate shows a sustained release from the Fenistil hydrocortisone ointment. The release of HC-acetate from the Ebenol-ointment is between that of the Soventol HC cream and that of the Fenistil-ointment. In summary, HC-acetate shows a shorter mean liberation time (MDT) and a higher topical availability from Soventol HC cream in comparison to the other formulations studied.