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Telodendrimer-based nanocarriers for the treatment of ovarian cancer

机译:基于Telodendrimer的纳米载体可治疗卵巢癌

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摘要

PEG-dendritic block copolymer (telodendrimer) is a unique class of polymers with well-defined structures and tunable aggregation properties, which have been recently developed as novel micelle-based nanocarriers. This new class of nanocarrier is highly versatile, robust, multifunctional and has many unique properties for drug delivery that are superior to most other nanocarriers reported in the literature. Reversible crosslinking of micelles is able to minimize the premature drug release during circulation. These crosslinks can be reversed with endogenous and/or exogenous stimuli. To further facilitate the precise delivery of nanoparticle drugs to cancer cells, the nanoparticles surface can be decorated with ovarian cancer targeting ligands. This review is focused on the various strategies used for the design, preparation, pharmacokinetic, biodistribution and preclinical therapeutic applications of telodendrimer-based nanocarriers for drug delivery in the treatment of ovarian cancer. Lastly, future perspectives for the development of ovarian cancer-targeting telodendrimer nanotherapeutics are also explored.
机译:PEG-树状嵌段共聚物(telodendrimer)是一类独特的聚合物,具有良好的结构和可调节的聚集特性,最近已被开发为新型的基于胶束的纳米载体。这类新型的纳米载体具有高度的通用性,坚固性,多功能性,并且具有许多独特的药物传递特性,优于文献中报道的大多数其他纳米载体。胶束的可逆交联能够最大程度地减少循环过程中药物的过早释放。这些交联可以被内源性和/或外源性刺激逆转。为了进一步促进纳米颗粒药物向癌细胞的精确递送,可以用卵巢癌靶向配体修饰纳米颗粒表面。这篇综述的重点是基于telodendrimer的纳米载体在卵巢癌治疗中的设计,制备,药代动力学,生物分布和临床前治疗应用的各种策略。最后,还探讨了靶向卵巢癌的telendendrimer纳米疗法的发展前景。

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