Subcutaneous administration of monoclonal antibodies: a small space to inject, a big challenge to conquer.

Mohammed Shameem

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Subcutaneous administration of monoclonal antibodies: a small space to inject, a big challenge to conquer.

机译：皮下注射单克隆抗体：注射空间小，征服难度大。

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Novel preactivated carboxymethyl cellulose represents a versatile excipient for drug delivery.

机译：新型的预活化羧甲基纤维素代表了一种用于药物输送的通用赋形剂。

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《Therapeutic delivery》 |2016年第1期|共2页
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Mohammed Shameem;
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正文语种 eng
中图分类临床医学;
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1. Subcutaneous administration of monoclonal antibodies: a small space to inject, a big challenge to conquer. [J] . Mohammed Shameem Therapeutic delivery . 2016,第1期

机译：皮下注射单克隆抗体：注射空间小，征服难度大。
2. In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies [J] . Bown Hanne Kinnunen, Bonn Catherine, Yohe Stefan, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2018,第期

机译：用于预测皮下注射单克隆抗体的生物利用度的体外模型
3. Golimumab, a human anti-tumor necrosis factor monoclonal antibody, injected subcutaneously every 4 weeks in patients with active rheumatoid arthritis who had never taken methotrexate: 1-year and 2-year clinical, radiologic, and physical function findings of a phase III, multicenter, randomized, double-blind, placebo-controlled study [J] . EmeryP., FleischmannR.M., DoyleM.K., Arthritis care & research . 2013,第11期

机译：Golimumab，一种人类抗肿瘤坏死因子单克隆抗体，每隔4周皮下注射一次从未服用过甲氨蝶呤的活动性类风湿关节炎患者：III期，多中心的1年和2年临床，影像学和身体功能检查结果，随机，双盲，安慰剂对照研究
4. Multivariate Analysis of Formulation and Molecular Attributes on Monoclonal Antibody Absorption upon Subcutaneous Administration [C] . Jayant Arora, Erica Schlesinger, Ana Campor, Protein Engineering Summit. . 2018

机译：皮下施用单克隆抗体吸收对单克隆抗体吸收的分子属性的多变量分析
5. Challenges Facing the Subcutaneous Administration of Therapeutic Monoclonal Antibodies [D] . Turner, Michael R. 2019

机译：皮下给药治疗性单克隆抗体面临的挑战
6. Characterization of Co-Formulated High-Concentration Broadly Neutralizing Anti-HIV-1 Monoclonal Antibodies for Subcutaneous Administration [O] . Vaneet K. Sharma, Bijay Misra, Kevin T. McManus, 2020

机译：用于皮下施用共同配制的高浓度宽度中和抗HIV-1单克隆抗体的表征
7. Golimumab, a human anti–tumor necrosis factor monoclonal antibody, injected subcutaneously every 4 weeks in patients with active rheumatoid arthritis who had never taken methotrexate: 1-year and 2-year clinical, radiologic, and physical function findings of a phase III, multicenter, randomized, double-blind, placebo-controlled study. [O] . Emery, Paul, Fleischmann, Roy M, Doyle, Mittie K, 2013

机译：Golimumab是一种人类抗肿瘤坏死因子单克隆抗体，每4周皮下注射一次从未服用过甲氨蝶呤的活动性类风湿关节炎患者：III期，多中心的1年和2年临床，影像学和身体功能检查结果，随机，双盲，安慰剂对照研究。

Subcutaneous administration of monoclonal antibodies: a small space to inject, a big challenge to conquer.

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